Intravenous phentolamine abolishes coronary vasoconstriction in response to mild central hypovolemia
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چکیده
منابع مشابه
Intravenous phentolamine abolishes coronary vasoconstriction in response to mild central hypovolemia.
Animal studies indicate alpha-adrenergic coronary vasoconstriction helps maintain left ventricular function during physiological stress. Whether this process occurs in humans is unknown. In the current study, we used transthoracic Doppler echocardiography to test the effect of lower body negative pressure (LBNP) on coronary blood flow velocity (CBV, left anterior descending coronary artery) and...
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In healthy subjects, variation in cardiovascular responses to sympathetic stimulation evoked by submaximal lower body negative pressure (LBNP) is considerable. This study addressed the question whether inter-subject variation in cardiovascular responses coincides with consistent and reproducible responses in an individual subject. In 10 healthy subjects (5 female, median age 22 years), continuo...
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THE recognition of the importance of the sympathetic nervous system in the control of the systemic arterial blood pressure has stimulated the search for therapeutically useful sympathoadrenergic blocking agents that may be of use in the diagnosis and treatment of hypertensive vascular disease. Numerous agents of diverse chemical structure have been developed and explored for such therapeutic ef...
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Nineteen patients with chronic low output cardiac failure were studied before, during and after infusion of phentolamine in doses of 10, 20, 30 and 40 microgram/kg/min. Significant reduction of left- and right-sided pressures and increases in cardiac index and heart rate (HR) were present within 15 minutes of starting phentolamine at the 10 microgram/kg/min dose. Minimal additional effect was o...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2014
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.01048.2013